021-51111890
购物车（0）
sales@molnova.cn
CGRP II, rat
CAS No. 99889-63-1
CGRP II, rat ( Calcitonin Gene Related Peptide (CGRP) II, rat )
产品货号. M29901 CAS No. 99889-63-1
Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
生物学信息
-
产品名称CGRP II, rat
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
-
产品描述Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
-
体外实验Calcitonin Gene Related Peptide (CGRP) II, rat induces vasodilator effects in small-diameter pig left anterior descending (LAD) coronary arteries with an EC50 value of 0.56 nM.Calcitonin Gene Related Peptide (CGRP) II, rat relaxes the spontaneous tone in isolated internal anal sphincter (IAS) strips, with an EC50 value of 83 μM.Calcitonin Gene Related Peptide (CGRP) II, rat (rβCGRP) inhibits [125I]hαCGRP binding (IC50: 7 nM), and stimulates cAMP accumulation (EC50: 0.56 nM) in the cells co-expressing mRAMP1 (mouse receptor-activity-modifying-protein 1) and rCRLR (rat calcitonin receptor-like receptor).Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, 0.01-100 nM) induces endothelium-independent relaxations in the coronary arteries from male and female Sprague-Dawley rats, with an IC50 value of 2.8 nM approximately.
-
体内实验Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, bolus injection, 0.3 μg/kg, at 10 min intervals) induces hypotension and vasodilatation in Male Sprague-Dawley rats. Animal Model:Male Sprague-Dawley rats.Dosage:0.01 ng/kg-3 μg/kg (100 μL), succeeded by a 150 μL isotonic saline flush, at 10 min intervals.Administration:A bolus injection Result:Induced PA (pial artery) dilatation and increased in LCBFFlux (local cortical cerebral blood flow).
-
同义词Calcitonin Gene Related Peptide (CGRP) II, rat
-
通路Others
-
靶点Other Targets
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number99889-63-1
-
分子量3805.31
-
分子式C163H267N51O50S2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES——
-
化学全称Sequence:{Ser}{Cys}{Asn}{Thr}{Ala}{Thr}{Cys}{Val}{Thr}{His}{Arg}{Leu}{Ala}{Gly}{Leu}{Leu}{Ser}{Arg}{Ser}{Gly}{Gly}{Val}{Val}{Lys}{Asp}{Asn}{Phe}{Val}{Pro}{Thr}{Asn}{Val}{Gly}{Ser}{Lys}{Ala}{Phe}-NH2 (Disulfide bridge: Cys2-Cys7)
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
Beglinger C, et al. Calcitonin gene-related peptides I and II and calcitonin: distinct effects on gastric acid secretion in humans. Gastroenterology. 1988 Oct;95(4):958-65.
产品手册
关联产品
-
Methyl-2-Butyl-Butyr...
Methyl-2-Butyl-Butyrate (2-methylbutyl butyrate) is a RIFM flavor.
-
Saikosaponin C
Saikosaponin C 通过抑制 caspase-3 激活和 caspase-3 介导的 FAK 降解，有效抑制 LPS 诱导的细胞凋亡。
-
Delta-Gluconolactone
葡萄糖酸内酯是一种天然存在的食品添加剂，用作螯合剂、酸化剂或固化剂、酸洗剂或膨松剂。
