CCT018159 ( —— )

产品货号. M21862 CAS No. 171009-07-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

CCT018159
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

热休克蛋白 90 (Hsp90) 是一种分子伴侣，可激活和维持多种客户蛋白的生物功能，其中许多与致癌信号通路相关。
产品描述

The heat shock protein 90 (Hsp90) is a molecular chaperone that activates and maintains the biological functioning of several client proteins, many of which are associated with oncogenic signaling pathways. Its activity is driven by ATP and regulated by co-chaperones such as Hsp72. CCT018159 is a 3,4-diaryl pyrazoloresorcinol compound that inhibits the ATPase activity of Hsp90 with IC50 values of 3.2 and 6.6 μM for human Hsp90β and yeast Hsp90, respectively.At concentrations up to 100 μM, CCT018159 does not inhibit human Hsp72 ATPase or topoisomerase II, yet at 50 μM CCT018159 inhibits 13 out of a panel of 20 commonly studied kinases.
体外实验

——
体内实验

——
同义词

——
通路

Others
靶点

Other Targets
受体

——
研究领域

——
适应症

——

CAS Number

171009-07-7
分子量

352.4
分子式

C20H20N2O4
纯度

>98% (HPLC)
溶解度

DMSO: 30 mg/ml
SMILES

CCc1cc(c(O)cc1O)c1n[nH]c(C)c1c1ccc2OCCOc2c1
化学全称

4-[4-(2,3-dihydo-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol