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CAY10404

CAS No. 340267-36-9

CAY10404 ( 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T )

产品货号. M22378 CAS No. 340267-36-9

CAY10404 是一种有效的、高选择性的 COX-2 和 COX-1 抑制剂。它也是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSCLC 细胞凋亡,具有镇痛、抗炎和抗癌活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥389 有现货
5MG ¥648 有现货
10MG ¥1191 有现货
25MG ¥2527 有现货
50MG ¥4301 有现货
100MG ¥6221 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CAY10404
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CAY10404 是一种有效的、高选择性的 COX-2 和 COX-1 抑制剂。它也是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSCLC 细胞凋亡,具有镇痛、抗炎和抗癌活性。
  • 产品描述
    CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells, with analgesic, anti-inflammatory and anti-cancer activities.Treatment with CAY10404 in the range of 10-100 microM caused dose-dependent growth inhibition, with an average 50% inhibitory concentration (IC(50)) of 60-100 micromol/L, depending on the cell line.?Western blot analysis of CAY10404-treated cells showed cleavage of poly (ADP-ribose) polymerase (PARP) and procaspase-3, signifying caspase activity and apoptotic cell death.?CAY10404 treatment inhibited the phosphorylation of Akt, glycogen synthase kinase-3beta and extracellular signal-regulated kinases 1/2 in H460 and H358 cells.
  • 体外实验
    CAY10404 (compound 7) exhibits no inhibition of COX-1 (IC50>500 μM). CAY10404 (10-100 μM; for 3 days) inhibits the growth of NSCLC cell lines in a concentration-dependent manner and has an average 50% inhibitory concentration (IC50) of 60-100 μM. CAY10404 (20-100 μM; for 3 days) induces apoptosis in NSCLC cells. CAY10404 (80 μM; for 3 days) induces a concentration-dependent decrease in the level of the anti-apoptotic proteins (Bcl-2 and Bcl-XL) and pAkt and pGSK-3β. CAY10404 (20, 50, 80, 100 μM; for 14 days) compromises the ability of H460 cells to form colonies in anchorage-independent growth in a concentration-dependent manner. Cell Viability Assay Cell Line:Non-small cell lung cancer (NSCLC) cells (H1703, H358, H460) Concentration:10-100 μM Incubation Time:For 3 days Result:Inhibited the growth of NSCLC cell lines in a concentration-dependent manner.Apoptosis Analysis Cell Line:H460 cells Concentration:20, 50, 100 μM Incubation Time:For 3 days Result:Induced apoptosis.Western Blot Analysis Cell Line:NSCLC cells (H358, H460) Concentration:80 μM Incubation Time:For 3 days Result:Induced a concentration-dependent decrease in the level of the anti-apoptotic proteins (Bcl-2 and Bcl-XL) and pAkt and pGSK-3β, without changing the level of the pro-apoptotic protein (Bax) and total Akt and GSK-3β protein levels.
  • 体内实验
    CAY10404 (50 mg/kg/day; ip; for 4 days) decreases lung inflammation in HTV mice and attenuates ventilator-induced lung injury. Animal Model:Adult male C57Bl/6J mice weighing 24-30 g Dosage:50 mg/kg Administration:IP; daily; for 4 days Result: Attenuated cyclooxygenase activity, significantly decreasing BAL PGE2 and 6-keto PGF1α. Decreased lung inflammation in HTV mice (high tidal volume; 20 ml/kg; for 4 hours) and attenuates ventilator-induced lung injury.
  • 同义词
    3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T
  • 通路
    Chromatin/Epigenetic
  • 靶点
    COX
  • 受体
    COX-1|COX-2|Akt
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    340267-36-9
  • 分子量
    367.34
  • 分子式
    C17H12F3NO3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 100 mg/mL (272.23 mM)
  • SMILES
    CS(=O)(=O)c1ccc(cc1)-c1noc(c1-c1ccccc1)C(F)(F)F
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Yongseon Cho, et al. Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. Respirology. 2009 Aug;14(6):850-8.
产品手册
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