CARM1-IN-7g ( Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor )

产品货号. M10096 CAS No. 1020399-49-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

CARM1-IN-7g
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CARM1-IN-7g 是一种有效的、选择性的共激活剂相关精氨酸甲基转移酶 1 (CARM1)，IC50 为 8.6 uM。
产品描述

CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7); inhibits CARM1-mediated methylation of different substrates (PABP1, CA150, SmB, and H3) up to single-digit micromolar level, significantly and dose-dependently reduces the prostate-specific antigen (PSA) promoter activity in human prostate cancer LNCaP cells, does not affect cell viability.
体外实验

——
体内实验

——
同义词

Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor
通路

Chromatin/Epigenetic
靶点

HMTase
受体

HMTase
研究领域

Cancer
适应症

——

CAS Number

1020399-49-8
分子量

555.2578
分子式

C26H21Br2NO3
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 35 mg/mL
SMILES

O=C1/C(CN(CC2=CC=CC=C2)C/C1=C/C3=CC=C(O)C(Br)=C3)=C\C4=CC=C(O)C(Br)=C4
化学全称

4-Piperidinone, 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-