Butin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Butin 是从黄檀的心材中分离出的主要的一种生物活性黄酮类化合物，具有很强的抗氧化、抗血小板和抗炎活性。在大鼠中，Butin 能显著减轻心肌梗死现象，改善心脏功能，预防糖尿病引起的心脏氧化损伤。

Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat.

Butin (10-40 mg/kg，口服，一天两次，15 天) 能够显著减轻糖尿病小鼠心肌缺血再灌注损伤，改善心脏功能，提高抗氧化应激能力。Butin (25-50 mg/kg，腹腔注射，单次剂量) 可通过减少细胞凋亡和炎症反应来减轻脑出血大鼠的行为改变和神经元状况。Animal Model:C57/BL6J mice induced by STZ Dosage:10, 20, 40 mg/kg; twice a day; 15 days Administration:OralResult:Improved cardiac function, significant increases in LVSP, +dP/dtmax and -dP/dtmin, reduced myocardial infarction area, reduced caspase-3 activity and Bax/Bcl-2 ratio, reduced GSH-px, GSH, SOD, CAT and GR activity.Animal Model:Intracerebral hemorrhage rats Dosage:25, 50 mg/kg; single dose Administration:Intraperitoneal injection (i.p.)Result:Increased the neurological score, significantly reduced the volume of hemorrhagic lesions, significantly reduced the Bax/Bcl-2 ratio and caspase-3 protein expression, and significantly reduced brain tissue inflammatory mediators tumor necrosis factor-α (TNF-α) and interleukin. Reduced levels of 6 (IL-6).

Butin (12.5-50 μM，6 h) 在 H9c2 细胞中减少由 I/R 损伤引起的细胞凋亡和死亡，且具有剂量依赖性。Butin (12.5-50 μM，6 h) 以剂量依赖的方式破坏了 Nrf2 与 Keap1 的相互作用。Butin (12.5-50 μM，6 h) 提高抗氧化基因在 mRNA 和蛋白水平上的表达。Cell Viability Assay Cell Line:H9c2 Concentration:12.5, 25, 50 μM Incubation Time:6 h Result:Increased cell survival in a dose-dependent manner.Western Blot Analysis Cell Line:H9c2 Concentration:12.5, 25, 50 μM Incubation Time:6 h Result:Increased the expression of GSH-px, GSH, SOD, CAT and HO-1.Real Time qPCR Cell Line:H9c2 Concentration:12.5, 25, 50 μM Incubation Time:6 h Result:Increased the levels of Nrf2 in the cytoplasm and nucleus in a dose-dependent manner and enhanced the expressions of GSH-px, GSH, SOD, CAT and HO-1.

紫铆亭

Others

Other Targets

Others

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21913-99-5

272.25

C15H12O5

>98% (HPLC)

DMSO : 100 mg/mL (367.30 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years