Bis(maltolato)oxovanadium(IV)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BMOV 是一种有效、可逆、竞争性和口服活性的泛 PTP（蛋白酪氨酸磷酸酶）抑制剂，具有模拟胰岛素作用和抗糖尿病特性。

BMOV is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitize. BMOV is shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectivelyr.(In Vitro):BMOV treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. BMOV treatment also resultes in an increased glucose uptake in C2C12 cells.(In Vivo):BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.

Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells.

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice. Animal Model:C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD) Dosage:0.75-3.0 mmol Administration:Intraperitoneal injection; twice weekly; for 6 weeks Result:Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.

BMOV | Bis(maltolato)oxovanadium (IV)

Metabolic Enzyme/Protease

Phosphatase

Apoptosis

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38213-69-3

317.15

C12H10O7V

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (78.83 mM)

CC(OC=C1)=C([O-]2)C1=O[V+2]23(O=C4C=COC(C)=C4[O-]3)=O

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(-20℃)

With Ice Pack

≥ 2 years