Beta-Sitosterol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

最近显示，β-谷甾醇可通过 Bcl-2 和 PI3K/Akt 信号通路诱导 G2/M 期阻滞、核内复制和细胞凋亡。

β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. β-Sitosterol, a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Although the exact mechanism of action of β-sitosterols is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). β-Sitosterol induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells.(In Vitro):Beta-Sitosterol is one of the most abundant dietary phytosterols. Beta-Sitosterol shows anticancer properties against breast cancer, prostate cancer, colon cancer, lung cancer, stomach cancer, ovarian cancer, and leukemia.

Cell Cytotoxicity Assay Cell Line:MDA-MB-231 Concentration:16 μM Incubation Time:3 days Result:No cytotoxicity at 16 μM Apoptosis Analysis Cell Line:MDA-MB-231 Concentration:16 μM Incubation Time:5 days Result:Increased 33% apoptosis when assayed using 1×104 cells and a 6-fold increase in apoptosis when assayed using a smaller number of cells 5×103.Western Blot Analysis Cell Line:COLO 320 DM Concentration:15, 30, 60, 120 μM Incubation Time:24 h Result:Decreased β-catenin and PCNA expression.

Animal Model:Colon cancer rats model Dosage:10, 20 mg/kg Administration:p.o., suspended in 0.1% CMC (1.0 mL)Result:Reduced the number of aberrant crypt and crypt multiplicity in a dose-dependent manner.Animal Model:Streptozotocin-induced hyperglycemia rats model Dosage:10, 15, 20 mg/kg Administration:p.o.Result:Increased insulin levels and decreased HbA1c levels.Improved pancreatic antioxidant levels and decreased LPO levels.

β-Sitosterol | 22,23-Dihydrostigmasterol

Others

Other Targets

PPL

Metabolic Disease

——

83-46-5

414.72

C29H50O

>98% (HPLC)

DMSO : < 1 mg/mL; H2O : < 0.1 mg/mL

[C@@H]1(O)CC2=CC[C@@H]3[C@@H]([C@]2(CC1)C)CC[C@]1([C@H]3CC[C@@H]1[C@@H](CC[C@H](C(C)C)CC)C)C

(24R)-Ethylcholest-5-en-3beta-ol

(-20℃)

With Ice Pack

≥ 2 years