Basiliximab ( —— )

产品货号. M36560 CAS No. 179045-86-4

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HNMR

HPLC

MSDS

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产品名称

Basiliximab
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Basiliximab (CHI 621) 是一种重组嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 抗体。Basiliximab 可用于肾移植研究。
产品描述

Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation.
体外实验

Basiliximab specifically inhibits T lymphocyte proliferation by binding to the IL-2Rα.Basiliximab binds only to activated lymphocytes and macrophages/monocytes. Basiliximab does not affect resting T lymphocytes that do not express IL-2Rα.
体内实验

Basiliximab (CHI 621) (0.07 mg/rat; i.v.; once) decreases total placental natural killer cells in reduced uterine perfusion pressure (RUPP) rats.Animal Model:Timed-pregnant Sprague Dawley (SD) rats, reduced uterine perfusion pressure (RUPP) rat model of placental ischemia Dosage:0.07 mg/rat Administration:IV infusion, once Result:Decreased total placental natural killer cells. Had no effect to lower MAP or improve pup weight and placental weight.
同义词

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通路

Others
靶点

Other Targets
受体

Interleukin
研究领域

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适应症

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1. McKeage K, et al. Basiliximab: a review of its use as induction therapy in renal transplantation. BioDrugs. 2010 Feb 1;24(1):55-76.?

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