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BRD-73954
CAS No. 1440209-96-0
BRD-73954 ( BRD73954 )
产品货号. M11867 CAS No. 1440209-96-0
第一个 HDAC6/8 双抑制剂，IC50 为 36/120 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥405 | 有现货 |
|
| 5MG | ￥729 | 有现货 |
|
| 10MG | ￥1223 | 有现货 |
|
| 25MG | ￥2454 | 有现货 |
|
| 50MG | ￥3710 | 有现货 |
|
| 100MG | ￥5451 | 有现货 |
|
| 500MG | ￥11583 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BRD-73954
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述第一个 HDAC6/8 双抑制剂，IC50 为 36/120 nM。
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产品描述The first HDAC6/8 dual inhibitor with IC50s of 36/120 nM; show no significant inhibition for other HDAC isoforms (IC50>9 uM); robustly increase in α-tubulin acetylation, has no change in the acetylation state of H3 in Hela cells.
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体外实验BRD73954 (10 μM; 48 h; HeLa cells) inhibits HDAC6 activity via upregulation of Ac-Tubulin. Western Blot Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:48 hours Result:Increased inα-tubulin acetylation, no change in the acetylation state of H3 was observed.
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体内实验——
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同义词BRD73954
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC2|HDAC4|HDAC6|HDAC8
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研究领域Cancer
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适应症——
化学信息
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CAS Number1440209-96-0
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分子量284.3098
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分子式C16H16N2O3
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 35 mg/mL
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SMILESC1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO
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化学全称1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Olson DE, et al. J Med Chem. 2013 Jun 13;56(11):4816-20.
