BOS-318

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BOS-318 是一种 Furin 抑制剂，具有缓慢解离、高选择性和细胞渗透性的特点。

BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.(In Vitro):BOS-318 (0.001-1 μM) provides cytoprotection against toxicity in CuFi-1 cells induced by P aeruginosa exotoxin A (PEA). BOS-318 (U2OS cells) to be approximately 13 times more potent against furin than PCSK5 (IC50 = 25.3 nM), 24 times more potent that PCSK7 (IC50 = 45.8 nM), and 110 times more potent than PCSK6 (IC50 = 209.4 nM). BOS-318 (0.3 μM, 2h or 48 h)reduces ENaC-mediated Na+ absorption in CF HBECs and protects aganist NE- and CF sputum-sol-mediated activation of ENaC.

BOS-318 (0.001-1 μM, 72 hours) provides cytoprotection against toxicity in CuFi-1 cells induced by P aeruginosa exotoxin A (PEA).BOS-318 (U2OS cells) to be approximately 13 times more potent against furin than PCSK5 (IC50 = 25.3 nM), 24 times more potent than PCSK7 (IC50 = 45.8 nM), and 110 times more potent than PCSK6 (IC50 = 209.4 nM) .BOS-318 (0.3 μM, 2 hours or 48 hours) reduces ENaC-mediated Na+ absorption in CF HBECs and protects against NE- and CF sputum-sol-mediated activation of the ENaC.Cell Viability AssayCell Line:CuFi-1 cells Concentration:17.4 and 263.0 nM Incubation Time:2 and 48 hours Result:Significantly inhibited ENaC-mediated Na+ transport as measured in differentiated human bronchial epithelial cells under both short- (IC50= 263.0 nM) and long-term (IC50= 17.4 nM) treatment conditions.Cell Viability Assay Cell Line:CuFi-1 cells Concentration:0.3 μM Incubation Time:72 hours Result:Significantly increased cell viability in PEA-treated cells to approximately 88% of control levels.Cell Cytotoxicity Assay Cell Line:CuFi-1 cells Concentration:0.001, 0.01, 0.03, 0.1, 0.3 and 1 μM Incubation Time:72 hours Result:Provided protection against PEA-mediated cytotoxicity in a dose-dependent manner, over a period of 72 h, with an EC50 of 47.8 nM.

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Others

Other Targets

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2387633-15-8

423.38

C17H31NO7P2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (87.49 mM)

CCCCCCCCCCOc1ccc[n+](CC(P([O-])(O)=O)P(O)(O)=O)c1

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(-20℃)

With Ice Pack

≥ 2 years