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BMS626529

CAS No. 701213-36-7

BMS626529 ( BMS626529 | BMS 626529 | Temsavir )

产品货号. M19017 CAS No. 701213-36-7

BMS-626529 是一种新型附着抑制剂,针对 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥478 有现货
5MG ¥786 有现货
10MG ¥1320 有现货
25MG ¥2406 有现货
50MG ¥4277 有现货
100MG ¥6229 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    BMS626529
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    BMS-626529 是一种新型附着抑制剂,针对 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。
  • 产品描述
    Temsavir, also known as BMS-626529, is a potent HIV-1 attachment inhibitor. BMS-663068 is also the phosphonooxymethyl prodrug of BMS-626529 that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates; however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses.(In Vitro):Temsavir has half-maximal effective concentration (EC50) values of <10 nM against the vast majority of viral isolates. Temsavir exhibits an average EC50 against LAI virus of 0.7±0.4 nM. Temsavir exhibits an EC50 of 0.01 nM against the most susceptible virus and an EC50 of >2,000 nM against the least susceptible virus. The cytotoxicity profile of Temsavir is examined in several cell types from different human tissues. CC50 values of >200 μM are observed in MT-2 (T lymphocytes), HEK293 (kidney), HEp-2 (larynx), HepG2 (liver), HeLa (cervix), HCT116 (colorectal), MCF-7 (breast), SK-N-MC (neuroepithelium), HOS (bone), H292 (lung), and MDBK (bovine kidney) cells measured after 3 or 6 days in culture. CC50 values of 105 and 192 μM are obtained in the T-cell line PM1 and in PBMCs, respectively, following 6 days in culture. These results show that Temsavir exhibits low cytotoxicity in cell culture. Temsavir exhibits a broad spectrum of antiviral activity against a panel of clinical isolates, with a 50% inhibitory concentration (IC50) ranging from subnanomolar levels to >0.1 μM.
  • 体外实验
    Temsavir has half-maximal effective concentration (EC50) values of <10 nM against the vast majority of viral isolates. Temsavir exhibits an average EC50 against LAI virus of 0.7±0.4 nM. Temsavir exhibits an EC50 of 0.01 nM against the most susceptible virus and an EC50 of >2,000 nM against the least susceptible virus. The cytotoxicity profile of Temsavir is examined in several cell types from different human tissues. CC50 values of >200 μM are observed in MT-2 (T lymphocytes), HEK293 (kidney), HEp-2 (larynx), HepG2 (liver), HeLa (cervix), HCT116 (colorectal), MCF-7 (breast), SK-N-MC (neuroepithelium), HOS (bone), H292 (lung), and MDBK (bovine kidney) cells measured after 3 or 6 days in culture. CC50 values of 105 and 192 μM are obtained in the T-cell line PM1 and in PBMCs, respectively, following 6 days in culture. These results show that Temsavir exhibits low cytotoxicity in cell culture. Temsavir exhibits a broad spectrum of antiviral activity against a panel of clinical isolates, with a 50% inhibitory concentration (IC50) ranging from subnanomolar levels to >0.1 μM.
  • 体内实验
    ——
  • 同义词
    BMS626529 | BMS 626529 | Temsavir
  • 通路
    Microbiology/Virology
  • 靶点
    Antibiotic
  • 受体
    Others
  • 研究领域
    Infection
  • 适应症
    ——

化学信息

  • CAS Number
    701213-36-7
  • 分子量
    473.48
  • 分子式
    C24H23N7O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 16.67 mg/mL; 35.21 mM
  • SMILES
    O=C(c1ccccc1)N2CCN(CC2)C(=O)C(=O)c3cnc4c(ncc(OC)c34)n5cnc(C)n5
  • 化学全称
    1-(4-benzoylpiperazin-1-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Nowicka-Sans B, et al. Antimicrobial Agents and Chemotherapy (2012), 56(7), 3498-3507.
产品手册
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