
BMS626529
CAS No. 701213-36-7
BMS626529 ( BMS626529 | BMS 626529 | Temsavir )
产品货号. M19017 CAS No. 701213-36-7
BMS-626529 是一种新型附着抑制剂,针对 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥478 | 有现货 |
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5MG | ¥786 | 有现货 |
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10MG | ¥1320 | 有现货 |
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25MG | ¥2406 | 有现货 |
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50MG | ¥4277 | 有现货 |
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100MG | ¥6229 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BMS626529
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BMS-626529 是一种新型附着抑制剂,针对 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。
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产品描述Temsavir, also known as BMS-626529, is a potent HIV-1 attachment inhibitor. BMS-663068 is also the phosphonooxymethyl prodrug of BMS-626529 that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates; however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses.(In Vitro):Temsavir has half-maximal effective concentration (EC50) values of <10 nM against the vast majority of viral isolates. Temsavir exhibits an average EC50 against LAI virus of 0.7±0.4 nM. Temsavir exhibits an EC50 of 0.01 nM against the most susceptible virus and an EC50 of >2,000 nM against the least susceptible virus. The cytotoxicity profile of Temsavir is examined in several cell types from different human tissues. CC50 values of >200 μM are observed in MT-2 (T lymphocytes), HEK293 (kidney), HEp-2 (larynx), HepG2 (liver), HeLa (cervix), HCT116 (colorectal), MCF-7 (breast), SK-N-MC (neuroepithelium), HOS (bone), H292 (lung), and MDBK (bovine kidney) cells measured after 3 or 6 days in culture. CC50 values of 105 and 192 μM are obtained in the T-cell line PM1 and in PBMCs, respectively, following 6 days in culture. These results show that Temsavir exhibits low cytotoxicity in cell culture. Temsavir exhibits a broad spectrum of antiviral activity against a panel of clinical isolates, with a 50% inhibitory concentration (IC50) ranging from subnanomolar levels to >0.1 μM.
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体外实验Temsavir has half-maximal effective concentration (EC50) values of <10 nM against the vast majority of viral isolates. Temsavir exhibits an average EC50 against LAI virus of 0.7±0.4 nM. Temsavir exhibits an EC50 of 0.01 nM against the most susceptible virus and an EC50 of >2,000 nM against the least susceptible virus. The cytotoxicity profile of Temsavir is examined in several cell types from different human tissues. CC50 values of >200 μM are observed in MT-2 (T lymphocytes), HEK293 (kidney), HEp-2 (larynx), HepG2 (liver), HeLa (cervix), HCT116 (colorectal), MCF-7 (breast), SK-N-MC (neuroepithelium), HOS (bone), H292 (lung), and MDBK (bovine kidney) cells measured after 3 or 6 days in culture. CC50 values of 105 and 192 μM are obtained in the T-cell line PM1 and in PBMCs, respectively, following 6 days in culture. These results show that Temsavir exhibits low cytotoxicity in cell culture. Temsavir exhibits a broad spectrum of antiviral activity against a panel of clinical isolates, with a 50% inhibitory concentration (IC50) ranging from subnanomolar levels to >0.1 μM.
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体内实验——
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同义词BMS626529 | BMS 626529 | Temsavir
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通路Microbiology/Virology
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靶点Antibiotic
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受体Others
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研究领域Infection
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适应症——
化学信息
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CAS Number701213-36-7
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分子量473.48
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分子式C24H23N7O4
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 16.67 mg/mL; 35.21 mM
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SMILESO=C(c1ccccc1)N2CCN(CC2)C(=O)C(=O)c3cnc4c(ncc(OC)c34)n5cnc(C)n5
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化学全称1-(4-benzoylpiperazin-1-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Nowicka-Sans B, et al. Antimicrobial Agents and Chemotherapy (2012), 56(7), 3498-3507.
产品手册




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