BMS-P5 ( —— )

产品货号. M27535 CAS No. 1549811-36-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BMS-P5
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BMS-P5 是一种具有口服活性的特异性肽基精氨酸脱亚胺酶 4 (PAD4) 抑制剂。
产品描述

BMS-P5 is a specific and orally active Peptidylarginine Deiminase 4 (PAD4) inhibitor.
体外实验

BMS-P5 blocks calcium ionophore-induced citrullination of histone H3.BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM. Cell Viability Assay Cell Line:Neutrophils.Concentration:10 μM and 100 μM.Incubation Time:30 min followed by addition of DP42 or 5TGM1 CM.Result:Prevented MM-induced NET formation.
体内实验

BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice.BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression. Animal Model:Syngeneic mouse model of MM.Dosage:50 mg/kg.Administration:Oral gavage, twice a day beginning on day 3 after tumor cell injection.Result:Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.
同义词

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通路

Others
靶点

Other Targets
受体

COX|HO-1|NOS|Nrf2|PKC
研究领域

——
适应症

——

CAS Number

1549811-36-0
分子量

509.04
分子式

C27H33ClN6O2
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=CC(OC)=C2C(N=C(N2C)C3=CC4=CC=CN=C4N3CC5CC5)=C1)N6[C@H](CC[C@H](C6)N)C.Cl
化学全称

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1.Nam JW, et al. Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents. Chem Biodivers. 2013 Jul;10(7):1322-7.

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