BAY 11-7085

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

人内皮细胞中 ICAM-1、VCAM-1 和 E-选择素表达的抑制剂 (IC50=5-10 uM)。

An inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM); acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation; prevents PMA-induced NF-kappaB nuclear translocation; reduces swelling in both the rat carrageenan paw edema assay and in a rat adjuvant arthritis model.

BAY 11-7085 inhibits TNFa-induced surface expression of E-selectin, VCAM-1, and ICAM-1with IC50 values in the range of 5-10 μM. BAY 11-7085 stabilizes IκBα in a dose-dependent manner with an IC50 value of approximately 10 μM. There is a clear correlation between the concentration of drug that stabilized IκBα, the concentration that inhibits nuclear levels of NF-kB, and the concentration that inhibits adhesion molecule expression. BAY 11-7085 has been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. BAY 11-7085 (ECSCs) significantly inhibits the cell proliferation and DNA synthesis of ovarian endometriotic cyst stromal cells and induces apoptosis and the G0/G1 phase cell cycle arrest of these cells. BAY 11-7085 induces apoptosis of ECSCs by suppressing antiapoptotic proteins, and that caspase-3-, -8-, and -9-mediated cascades are involved in this mechanism.

BAY 11-7085 acts as an anti-inflammatory agent in both the rat carrageenan paw and the rat adjuvant arthritis model. It demonstrates a dose-dependent reduction in swelling in the rat carrageenan paw model.

BAY11-7085 | BAY-11-7085 | BAY 11-7083

Apoptosis

NF-κB

IκBα?phosphorylation

Inflammation/Immunology

——

196309-76-9

249.3287

C13H15NO2S

>98% (HPLC)

DMSO: ≥ 26 mg/mL

N#C/C=C/S(=O)(C1=CC=C(C(C)(C)C)C=C1)=O

2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)-

(-20℃)

With Ice Pack

≥ 2 years