Artefenomel ( OZ439 )

产品货号. M10144 CAS No. 1029939-86-3

Artefenomel (OZ439) 是一种新型的下一代抗疟臭氧化物，在体外对恶性疟原虫和体内伯氏疟原虫具有高效功效（K1/NF54，IC50=2.0/3.2 nM）。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥3039	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Artefenomel
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Artefenomel (OZ439) 是一种新型的下一代抗疟臭氧化物，在体外对恶性疟原虫和体内伯氏疟原虫具有高效功效（K1/NF54，IC50=2.0/3.2 nM）。
产品描述

Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM).Parasite Infection Phase 2 Clinical.
体外实验

Artefenomel (OZ439) (10 μg/mL, 2 h) can alkylate Plasmodium falciparum proteins. Artefenomel (0.3-300 μM) reduces ACE2 expression in Vero cells in a dose-dependent manner and does not induce any cytotoxicity at concentrations up to 300 μM.Artefenomel (33-100 μM) can completely prevent the virus-induced CPE and inhibit SARS-CoV-2 in a dose-dependent manner with an IC50 of 2.9 μM.Artefenomel (0-10 μg/mL) affects red blood cells and induces anaemia, thereby inducing histological changes (cell death) and macroscopic abnormalities in the embryo from pregnant Crl:CD(SD)BR rats. Cell Viability Assay Cell Line:embryos from pregnant Crl:CD(SD)BR rats Concentration:0.1, 1, 2, 5, 7.5, and 10 μg/mL Incubation Time:Result:Showed a slightly shortened tail or slightly delayed telencephalic vesicles at 5 μg/mL, a decrease in the number of circulating red blood cells at 7.5 μg/mL and an arrhythmogenic heartbeat at 10 μg/mL.
体内实验

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同义词

OZ439
通路

Microbiology/Virology
靶点

Parasite
受体

Parasite
研究领域

Infection
适应症

Parasite Infection

化学信息

CAS Number

1029939-86-3
分子量

469.622
分子式

C28H39NO5
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 4.2 mg/mL (8.94 mM)
SMILES

C1CC2(CCC1C3=CC=C(C=C3)OCCN4CCOCC4)OC5(C6CC7CC(C6)CC5C7)OO2
化学全称

4-[2-(4-cis-Dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decan]-4-ylphenoxy)ethyl]morpholine

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Dong Y, et al. J Med Chem. 2017 Apr 13;60(7):2654-2668. 2. Kim HS, et al. J Med Chem. 2017 Apr 13;60(7):2651-2653. 3. Macintyre F, et al. BMC Med. 2017 Oct 9;15(1):181. 4. Yang T, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4501-10.

计算器

浓度计算器

摩尔计算器

分子量计算器

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