Arteether

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Artemotil (β-Arteether) 具有抗疟疾活性，可用于研究耐 Plasmodium falciparum 的恶性疟原虫疟疾，IC50 值为 1.61 nM。Artemotiltil 对大鼠，狗和猴子具有 CNS 神经毒性和厌食毒性。

Arteether, a new antimalarial drug.(In Vitro):The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.(In Vivo):Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7).

The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.

Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7). Animal Model:Sprague-Dawley male rats (220-280 g)Dosage:25 mg/kg; 1 mL/kg body weight Administration:Intravenous injection; daily; for 7 days Result:Anorectic toxicity was observed, and that caused significant reductions in food consumption and body weight after day 2.

Artemotil | Dihydroartemisinin ethyl ether | NSC 665971

Autophagy

CCR

CCL4| CCL5| CXCL10| CXCL9

Infection

——

75887-54-6

312.4

C17H28O5

>98% (HPLC)

Soluble in DMSO

C[C@H]1[C@@H](OCC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin

(-20℃)

With Ice Pack

≥ 2 years