Aristeromycin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Aristeromycin，腺苷类似物，是一种抗生素和有效的S-腺苷同型半胱氨酸水解酶 (AHCY)抑制剂。

Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor.

The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 μM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM.Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth.At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a.

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Immunology/Inflammation

Antiviral

Antiviral

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19186-33-5

265.27

C11H15N5O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (188.49 mM; 超声助溶 (<60°C)

Nc1ncnc2n(cnc12)[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years