Apelin-13

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Apelin-13 是 APJ 受体的内源性配体。Apelin-13 可以防止缺血/再灌注 (I/R) 诱导的细胞凋亡。

Apelin-13 is an endogenous ligand of the APJ receptor.Apelin-13 could protect against apoptosis induced by ischemic/reperfusion (I/R).

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Apelin-13 (200 μg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum,induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels.Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons. Animal Model:Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)Dosage:200 μg/kg Administration:IP, daily for 4 weeks Result:Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.Animal Model:Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)Dosage:10 and100 μM Administration:ICV, single dosage Result:Increased the spontaneous discharges in the majority of pallidal neurons.

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Other Targets

Others

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217082-58-1

1550.83

C69H111N23O16S

>98% (HPLC)

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CSCCC(NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)NC(=O)C(N)CCC(N)=O)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years