Antihistamine-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Antihistamine-1 是一种 H1-抗组胺药（Ki：6.9 nM），具有可接受的血脑屏障渗透性，也是 CYP2D6 和 hERG 通道的抑制剂（IC50：5.4 和 0.8 μM）。

Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 and 0.8 μM).(In Vitro):Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.

Antihistamine-1 (Compound 2) is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.

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Metabolic Enzyme/Protease

P450

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1186430-60-3

389.478

C23H24FN5

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (64.19 mM)

Cc1cnn(c1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccc(F)cc1

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(-20℃)

With Ice Pack

≥ 2 years