Amitivir ( LY-217896 | LY 217896 | LY217896 )

产品货号. M27847 CAS No. 111393-84-1

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Amitivir
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

阿米替韦是一种肌苷单磷酸脱氢酶抑制剂。阿米替韦抑制分裂的 MDCK 细胞的复制。
产品描述

Amitivir is an inosine monophosphate dehydrogenase inhibitor. Amitivir inhibits the replication of dividing MDCK cells. Amitivir was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection.
体外实验

The mean 50% inhibitory concentration of Amitivir inhibits six strains of type A influenza (A/Russia, A/Brazil/11/78, A/Ann Arbor/1/57, A/Port Chalmers/1/73, A/Hong Kong/8/68 and A/X-15) ranged from 0.37 to 1.19 μg/ml. The mean 50% inhibitory concentration of Amitivir inhibits four strains of influenza B virus (B/Maryland/11/59, B/GreatLakes/1739/54, B/Singapore/3/64, B/Lee/40) ranged from 0.75 to 1.54 μg/ml.
体内实验

Amitivir (LY 217896) (9 mg/m2 of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus.
同义词

LY-217896 | LY 217896 | LY217896
通路

Others
靶点

Other Targets
受体

lipase
研究领域

——
适应症

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1.Muccioli GG, et al. CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. Chembiochem. 2008 Nov 3;9(16):2704-10.

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