Afzelin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Afzelin 具有多种细胞活性，例如 DNA 保护、抗菌、抗氧化、抗炎以及紫外线吸收活性，并且可以通过紫外线吸收和细胞活性的结合来保护人体皮肤免受 UVB 引起的损伤。

Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.(In Vitro):Therefore, in this study, we investigated the protective effects of Afzelin, one of the flavonoids, against UV irradiation in human keratinocytes and epidermal equivalent models. Spectrophotometric measurements revealed that the Afzelin extinction maxima were in the UVB and UVA range, and UV transmission below 376 nm was <10%, indicating UV-absorbing activity of Afzelin. In the phototoxicity assay using the 3T3 NRU phototoxicity test (3T3-NRU-PT), Afzelin presented a tendency to no phototoxic potential. In addition, in order to investigate cellular functions of Afzelin itself, cells were treated with Afzelin after UVB irradiation. In human keratinocyte, Afzelin effectively inhibited the UVB-mediated increase in lipid peroxidation and the formation of cyclobutane pyrimidine dimers. Afzelin also inhibited UVB-induced cell death in human keratinocytes by inhibiting intrinsic apoptotic signaling. Furthermore, Afzelin showed inhibitory effects on UVB-induced release of pro-inflammatory mediators such as interleukin-6, tumor necrosis factor-α±, and prostaglandin-E2 in human keratinocytes by interfering with the p38 kinase pathway. Using an epidermal equivalent model exposed to UVB radiation, anti-apoptotic activity of Afzelin was also confirmed together with a photoprotective effect at the morphological level.

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Kaempferol-3-O-rhamnoside

Others

PTEN

PTEN

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482-39-3

432.381

C21H20O10

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (289.10 mM)

C[C@@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years