AZA1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZA1 是 Rac1 和 Cdc42 的有效抑制剂。AZA1 诱导前列腺癌细胞凋亡并抑制增殖，迁移和侵袭。

AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.

AZA1 (Rac1/Cdc42-IN-1) (2-10 μM; 72 hours) blocks the proliferation of human prostate cancer cells 22Rv1 prostate cancer cells.AZA1 (2-10 μM; 24 hours) reduces phosphorylation of PAK1, AKT and BAD in EGF stimulated 22Rv1 prostate cancer cells.AZA1 (10 μM; 24 hours) blocks Rac1 and Cdc42-dependent cell cycle events in 22Rv1 prostate cancer cells.AZA1 blocks Rac1 and Cdc42-dependent migration of 22Rv1, DU 145 and PC-3 prostate cancer cells.AZA1 affects cell motility and actin rearrangement in prostate cancer cells by suppressing Rac1 and Cdc42 activity via PAK1/2 phosphorylation.Cell Proliferation Assay Cell Line:22Rv1 prostate cancer cells Concentration:2, 5, 10 μM Incubation Time:72 hours Result:Suppressed 22Rv1 prostate cancer cell proliferation in both unstimulated and EGF-stimulated cancer cells in a dose-dependent manner. Western Blot Analysis Cell Line:22Rv1 prostate cancer cells (EGF-stimulated)Concentration:2, 5, 10 μM Incubation Time:24 hours Result:Reduced phosphorylation of PAK1, AKT and BAD in EGF-stimulated 22Rv1 prostate cancer cells.

AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice and improving survival.Animal Model:5 week-old athymic nu/nu (nude) mice (bearing 22Rv1 prostate cancer cell xenografts)Dosage:100 μg in 100 μl 30% DMSO Administration:I.p.; daily for 2 weeks Result:The suppressive effect of AZA1 on tumor growth was significant.

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Cell Cycle/DNA Damage

Rho

Rho | Apoptosis | CDK

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1071098-42-4

368.43

C22H20N6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (135.71 mM; 超声助溶 )

Cc1cc2cc(Nc3ccnc(Nc4ccc5[nH]c(C)cc5c4)n3)ccc2[nH]1

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(-20℃)

With Ice Pack

≥ 2 years