AUTEN-67

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种小分子自噬增强剂，特异性抑制肌管蛋白相关磷酸酶 MTMR14；在 2、10 和 100 uM 浓度下，AUTEN-67 分别抑制 MTMR14 近 3%、25% 和 70%。

A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.

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Animal Model:Alzheimer disease model (Mice expressing the human APP)Dosage:19 mg/kg, 3 times a week for 3 month Administration:Oral administration Result:Restored nesting behavior by around 30%.Decreased Amyloid β levels in the hemibrain of mice.

Autophagy Enhancer 67 | AUTEN67

Autophagy

Autophagy

Autophagy

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1783800-77-0

474.45

C23H14N4O6S

>98% (HPLC)

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C1=CC=C2C(=C1)C(=O)C(=C(C2=O)N3C=NC4=CC=CC=C43)NS(=O)(=O)C5=CC=C(C=C5)[N+](=O)[O-]

N-(3-(1H-benzo[d]imidazol-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-nitrobenzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years