
ARN25068
CAS No. 2649882-80-2
ARN25068 ( —— )
产品货号. M35549 CAS No. 2649882-80-2
ARN25068 是三种蛋白激酶 GSK-3β、FYN 和 DYRK1A的亚微摩尔抑制剂,可解决 tau 蛋白过度磷酸化。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1486 | 有现货 |
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5MG | ¥2301 | 有现货 |
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10MG | ¥3739 | 有现货 |
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25MG | ¥7257 | 有现货 |
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50MG | ¥9775 | 有现货 |
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100MG | ¥12852 | 有现货 |
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500MG | ¥25857 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称ARN25068
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述ARN25068 是三种蛋白激酶 GSK-3β、FYN 和 DYRK1A的亚微摩尔抑制剂,可解决 tau 蛋白过度磷酸化。
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产品描述ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation.
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体外实验ARN25068 reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. ARN25068 exhibits IC50 values of 4.17 and 2.17 μM for GSK-3β and FYN in enzymatic radiometric assay, respectively.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Microtubule Associated | Src | DYRK | GSK-3
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研究领域——
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适应症——
化学信息
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CAS Number2649882-80-2
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分子量362.45
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分子式C19H18N6S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 200 mg/mL (551.80 mM; 超声助溶 )
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SMILESN(C1=C2C(=NC(NCC3=CC=CC=C3)=N1)C=CS2)C=4C=C(NN4)C5CC5
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.?
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