AR-9281

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AR9281 是一种有效的选择性可溶性环氧化物水解酶 (s-EH) 抑制剂，可用于治疗高血压和 2 型糖尿病。

AR9281 is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes.

AR-9281 (APAU) has inhibitory activity for human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively.

AR-9281 (APAU) (oral, 150-200 mg/dL, for 6 weeks) enhances the therapeutic effects of EETs, slows progression of hyperglycemia, protects the myocyte structure, and reduces Ca2+ dysregulation and SERCA remodeling in hyperglycemic rats. Animal Model:T2DM rat model Dosage:150-200 mg/dL Administration:oral(drinking), for 6 weeks Result:Attenuated the progressive increase of blood glucose concentration and preserved mitochondrial structure and myofibril morphology in cardiac myocytes.Protected the intracellular Ca2+ effector system. Had less downregulation of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) and lowed expression of hypertrophic markers.

APAU

Others

Other Targets

s-EH

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913548-29-5

319.44

C18H29N3O2

>98% (HPLC)

DMSO:25 mg/mL (78.26 mM; Need ultrasonic)

CC(=O)N1CCC(CC1)NC(=O)NC23CC4CC(CC(C4)C2)C3

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(-20℃)

With Ice Pack

≥ 2 years