8-M-PDOT

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

8-M-PDOT (AH-002) 是一种选择性的褪黑激素 MT2 受体激动剂。8-M-PDOT 对 MT2 的选择性是 MT1 受体的 5.2 倍。8-M-PDOT 结合人类重组 MT1 和 MT2 受体，其 pKi 值分别为 8.23 和 8.95。8-M-PDOT 具有抗焦虑活性。

8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.

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8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect.Animal Model:Male Wistar rats (280-320 g) with Rotenone Dosage:10 μg/μL Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes Result:Increased percentage of time spent in the open arms and in the number of open arms entries.

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Others

Other Targets

MT Receptor

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134865-70-6

233.31

C14H19NO2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (428.61 mM; 超声助溶 )

CCC(=O)NC1CCc2cccc(OC)c2C1

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(-20℃)

With Ice Pack

≥ 2 years