7α,25-Dihydroxycholesterol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

7α,25-二羟基胆固醇 (7α,25-OHC) 是孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。 7α, 25-二羟基胆固醇可以作为趋化因子指导 B 细胞、T 细胞和树突状细胞的迁移，并且能够高效激活 EBI2（EC50=140 pM；Kd=450 pM）。

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells, and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM. but it had no effect on EBI2-deficient cells[1].EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen.

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7α,25-OHC

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite|GPR183

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64907-22-8

418.65

C27H46O3

>98% (HPLC)

DMSO:1 mg/mL?(2.39 mM;?Need ultrasonic)

[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)(C)O

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(-20℃)

With Ice Pack

≥ 2 years