7-Hydroxymethotrexate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

7-Hydroxymethotrexate 是 Methotrexate (MTX; HY-14519) 的主要代谢产物。Methotrexate 是一种抗代谢和抗叶酸剂，可以抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸，并抑制 DNA 合成。

7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.

7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR markedly lower (>100-fold) than for Methotrexate (MTX) .

7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.Animal Model:Male Wistar rats (270-440 g)Dosage:4 mg/kg (Pharmacokinetic Analysis)Administration:IVResult:Had a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.

——

Others

Other Targets

Drug Metabolite

——

——

5939-37-7

470.44

C20H22N8O6

>98% (HPLC)

——

NC1=C2C(NC(=O)C(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=NC(N)=N1

——

(-20℃)

With Ice Pack

≥ 2 years