4-Methoxycoumarine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

4-Methoxycoumarine 具有抗肿瘤作用。Coumarin 在体内具有抗肿瘤作用，在体外具有细胞抑制作用。它在人体中的半衰期很短（1-1.5小时），而单羟基化生物转化产物的半衰期明显更长。

4-Methoxycoumarine has antitumour effects.Coumarin has antitumour effects in vivo and cytostatic effects in vitro. Its half-life in humans is short (1-1.5 h) and the monohydroxylated biotransformation products have significantly longer half-lives. One or several of these products may thus be responsible for the antitumoral effects. METHODS AND RESULTS: We have assayed the in vitro cytostatic activity of five monohydroxylated coumarins (3-, 4-, 6-, 7- and 8-monohydroxycoumarin), their acetates and methyl-ethers. Murine melanoma cells (cell line B16-F10) and murine fibroblasts (B82) were exposed to the test compounds at concentrations between 10 and 160 microg/ml. The cytostatic effects were estimated by reduction of the tetrazolium dye MTT. In the melanoma cells, some of the compounds inhibited growth after exposure for 1 day. In contrast, coumarin inhibited growth to a smaller extent, and only after exposure for 3 days. The most active compounds (3-acetoxycoumarin, 4-methoxycoumarin(4-Methoxycoumarine) and 6-hydroxycoumarin), as well as coumarin, were also assayed in murine fibroblasts. CONCLUSIONS: The cytostatic effects of 4-methoxycoumarin(4-Methoxycoumarine) and 6-hydroxycoumarin were less pronounced in fibroblasts than in melanoma cells. Our observations suggest that these compounds may have a greater therapeutic margin.

——

——

——

Others

Other Targets

Others

——

——

20280-81-3

176.17

C10H8O3

>98% (HPLC)

——

COc1cc(=O)oc2ccccc12

——

(-20℃)

With Ice Pack

≥ 2 years