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2614W94
CAS No. 205187-35-5
2614W94 ( —— )
产品货号. M26022 CAS No. 205187-35-5
2614W94 是一种选择性、竞争性、可逆的单胺氧化酶-A 抑制剂，以 5-羟色胺为底物，IC50 为 5 nM，Ki 为 1.6 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4026 | 有现货 |
|
| 10MG | ￥5856 | 有现货 |
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| 25MG | ￥9153 | 有现货 |
|
| 50MG | ￥12312 | 有现货 |
|
| 100MG | ￥16038 | 有现货 |
|
| 500MG | ￥32157 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称2614W94
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述2614W94 是一种选择性、竞争性、可逆的单胺氧化酶-A 抑制剂，以 5-羟色胺为底物，IC50 为 5 nM，Ki 为 1.6 nM。
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产品描述2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate.(In Vitro):2614W94 (30 nM) shows no inhibition of MAO-B.(In Vivo):In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg.
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体外实验2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM.
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体内实验2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED50 of 1.1 mg/kg.
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同义词——
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通路Others
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靶点Other Targets
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受体Alkyl-Chain
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研究领域——
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适应症——
化学信息
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CAS Number205187-35-5
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分子量344.3
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分子式C15H11F3O4S
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(Oc1ccc2c(Oc3ccccc3S2(=O)=O)c1)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
产品手册
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