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1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol
CAS No. 133740-30-4
1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol ( 1-(4-羟苄基)-4-甲氧基菲-2,7-二醇 )
产品货号. M38832 CAS No. 133740-30-4
BChE-IN-11 (compound 10) 是一种有效的、选择性的、非竞争性 BChE (丁基胆碱酯酶)抑制剂，其 IC50 为 2.1 μM。BChE-IN-11 可用于阿尔茨海默病 (AD) 的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥10881 | 有现货 |
|
| 50MG | 获取报价 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
生物学信息
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产品名称1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BChE-IN-11 (compound 10) 是一种有效的、选择性的、非竞争性 BChE (丁基胆碱酯酶)抑制剂，其 IC50 为 2.1 μM。BChE-IN-11 可用于阿尔茨海默病 (AD) 的研究。
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产品描述BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.
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体外实验———
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体内实验BChE-IN-11 (compound 10) shows inhibition activity for BChE and AChE, with inhibition of 96.6 ± 1.2% and 19.1 ± 3.8% at 25 μg/mL, respectively.BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82.
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同义词1-(4-羟苄基)-4-甲氧基菲-2,7-二醇
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通路Others
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靶点Other Targets
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受体BChE: 2.1\u2009±\u20090.3 μM (IC50), AChE
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研究领域———
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适应症———
化学信息
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CAS Number133740-30-4
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分子量346.38
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分子式C22H18O4
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纯度>98% (HPLC)
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溶解度———
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SMILES———
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化学全称———
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Liu Y, et al. Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors. Sci Rep. 2022 Aug 11;12(1):13649.?
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