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(4E)-SUN9221
CAS No. 222318-55-0
(4E)-SUN9221 ( —— )
产品货号. M33084 CAS No. 222318-55-0
(4E)-SUN9221 是一种有效的 α1-adrenergic receptor 和 5-HT2 receptor 拮抗剂，具有抗高血压和抗血小板聚集的功效。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥9044 | 有现货 |
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| 5MG | ￥14535 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称(4E)-SUN9221
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述(4E)-SUN9221 是一种有效的 α1-adrenergic receptor 和 5-HT2 receptor 拮抗剂，具有抗高血压和抗血小板聚集的功效。
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产品描述(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.
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体外实验(4E)-SUN9221 potently inhibits collagen-, ADP- and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, 14 nM, respectively, in human platelet-rich plasma (PRP). (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22).
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体内实验(4E)-SUN9221 (1, 3, 10 mg/kg, p.o.) reduces the blood pressure in a dose-dependent manner in conscious spontaneously hypertensive rats (SHR). (4E)-SUN9221 (3 mg/kg) exhibits antihypertensive activity in SHR.
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同义词——
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor | Adrenergic Receptor
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研究领域——
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适应症——
化学信息
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CAS Number222318-55-0
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分子量454.54
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分子式C25H31FN4O3
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纯度>98% (HPLC)
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溶解度——
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SMILESC(CCCN1CCC(C(=O)C2=CC=C(F)C=C2)CC1)N3C4=C(\C(=N\O)\CCN(C)C4=O)C=C3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mizuno A, et al. Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo). 1999 Feb;47(2):246-56.?
产品手册
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